Sainstech Farma: Jurnal Ilmu Kefarmasian

Determination of the Activity and Potential of Chalcone Compounds from Jambu Air Leaves (Eugenia aquea Burm f) Against T47D Breast Cancer Cells In Silico

Erwi Putri Setyaningsih, Resti Wulan Dari, Rosario Trijuliamos Manalu — Fri, 28 Feb 2025 13:12:10 +0000

Breast cancer is a malignant tumor caused by excessive expression of one or all three estrogen (ER) and progesterone (PR) proteins and Human Epidermal Growth Factor Receptor (HER2). Current breast cancer treatment generally uses chemotherapy, radiotherapy, hormone therapy, and surgery. The increasing need for new drugs with high selectivity, low toxicity, and good metabolic stability against breast cancer has led many researchers to explore Indonesia's natural resources to obtain drugs that have anticancer activity. Chalcone is a secondary metabolite of the flavonoid group with pharmacological activity as an anticancer. Four chalcone compounds in jambu air leaves (Eugenia aquea Burm f) have met the requirements for drug similarity testing. In silico research is the initial step in designing new drug discoveries because it is relatively faster and can handle thousands of compounds. This study aimed to determine the activity and potential of jambu air (Eugenia aquea Burm f) leaf chalcone compounds in inhibiting the target protein of breast cancer T47D cells in silico and its ADMET prediction. The research method is in silico, with molecular docking techniques using the YASARA View, Marvinsketch, PubChem, PLANTS, and Discovery Studio 2021 applications. The results of the molecular docking analysis of the target protein, namely, Myrigalon-b have the potential to inhibit HER2 protein, Myrigalon-g has the potential to inhibit ERα, and phloretin has the potential to inhibit ERβ. The ADMET prediction results of the Myrigalon-g and phloretin compounds have the best values.

Screening of Administration, Pharmaceutical, and Clinical Completeness in Patient E- Prescriptions at the Petir Public Health Center Tangerang City

Ritha widyapratiwi, Amelia Febriani, Fadia Husna — Thu, 13 Mar 2025 00:41:26 +0000

The completeness of prescription review must be carried out to prevent the occurrence of medication errors in e-prescription services. This study aims to determine the results of the study of the completeness of outpatient e- prescriptions for general poly patients at the Petir Public Health Center Tangerang City. This type of research is descriptive with a cross sectional approach and retrospective sampling with a total sample of 330 e- prescriptions. The results showed the completeness of the e-prescription administration in the patient's name 100%, age 100%, gender 100%, weight 99.70%, doctor's name 100%, doctor's SIP 56%, doctor's paraf 100%, and date of prescription writing 100%. In pharmaceutical terms, the dosage form 96.06%, dosage strength 98.48%, quantity of drugs 100%, rules and methods of use 97.27%, and incompatibility 100%. In clinical terms, the accuracy of dosage 88.18% and the potential for drug interactions 34.24% ,with 38.64% low interaction potential and 61.36% moderate interaction potential . It is hoped that the results of this study will encourage doctors and pharmacists to pay more attention to the completeness of e-prescriptions, thereby improving the service to patients, ensuring that treatment is adhered to and preventing medication errors in e-prescribing.

Evaluasi Rasionalitas Penggunaan Antihipertensi di Puskesmas Jagakarsa, Jakarta Selatan Periode Juli-Desember 2023

Kurniatul Hasanah, Siswati Siswati, Nur Azmi Adriyati — Fri, 17 Jan 2025 00:00:00 +0000

Hypertension is defined as a condition where an individual's systolic blood pressure is consistently above 140 mmHg and diastolic blood pressure is above 90 mmHg, as determined by two separate measurements. This condition represents a major public health challenge, with high rates of morbidity and mortality globally, particularly in Indonesia. The World Health Organization (WHO) estimates that 50% of all drugs worldwide are prescribed, dispensed, or sold inappropriately. This often leads to improper drug use by patients, resulting in adverse clinical and economic consequences. This can cause unwanted problems such as unachieved therapeutic goals and increased side effects of drugs. The purpose of this study was to determine the demographics of hypertensive patients, the characteristics of hypertensive patients, patterns of antihypertensive use and the rationality of antihypertensive use including appropriate indications, appropriate drugs and appropriate doses. This study was an observational retrospective study using a descriptive analysis design. The sample used was 166 patients who met the inclusion criteria. The results showed patient demographic data for female gender as many as 89 patients (53.62%) and male as many as 77 patients (46.39%). Based on age, the majority of patients were in the range of 46-55 years, as many as 51 people (30.72%). Based on disease characteristics, the majority of patients were in stage II hypertension, as many as 113 patients (68.07%). Based on complications or comorbidities, the majority of patients were hypertensive patients without complications and comorbidities, as many as 69 patients (41.57%). The most frequent use of antihypertensives was in the form of single therapy, as many as 146 patients (87.85%), namely the calcium channel blocker (amlodipine) drug group, as many as 139 patients (83.73%). The results of the evaluation of the rationality of antihypertensive use in the category of appropriate indications were 100% (166 patients), appropriate drugs were 100% (166 patients) and appropriate doses were 94.58% (157 patients). All samples examined demonstrated adherence to the principles of rational antihypertensive therapy, specifically regarding appropriate indications and drug selection. The aspect of appropriate doses reached 94.58%.