Sainstech Farma: Jurnal Ilmu Kefarmasian

Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Secang (Biancaea sappan L.) sebagai Obat Luka Bakar

Repining Tiyas Sawiji, Maria Ariyani Da Costa Kumanireng — Fri, 18 Jul 2025 00:00:00 +0000

Burns constitute damage to skin tissue caused by exposure to thermal, chemical, or electrical agents. The severity of burns can profoundly impact metabolic processes and cellular function. Although silver sulfadiazine is a common treatment, its prolonged use may induce skin irritation. Traditionally, secang leaves (Biancaea sappan L.) have demonstrated pharmacological effects that promote the accelerated healing of burn wounds. Given their flavonoid content, which is instrumental in stimulating wound healing, secang leaves hold promise for development into traditional medicinal preparations. Carbopol 940, a well-known gel-forming agent, is recognized for its influence on the physical properties of gel formulations. This study seeks to investigate the impact of different concentrations of Carbopol 940 on secang leaf extract gel preparations and to assess the physical stability of these gel formulations through the cycling test method. Secang leaf extract, used as an active ingredient, was formulated into three distinct gel preparations with varying concentrations of Carbopol 940 as a gelling agent: F1 (1%), FII (1.5%), and FIII (2%). The physical characteristics of these gel preparations were thoroughly tested, including organoleptic properties, homogeneity, pH, spreadability, stickiness, and viscosity. To assess stability, the gel preparations underwent a cycling test method, consisting of 6 cycles. Each cycle involved exposing the samples to a temperature of ± 4°C for 24 hours, followed by a hot temperature of ± 40°C for another 24 hours. The research findings indicate that variations in the concentration of Carbopol 940, along with the addition of TEA (Triethanolamine), significantly impacted the physical characteristics of the gel preparations. Specifically, an increase in Carbopol 940 concentration resulted in higher pH and viscosity, while spreadability and stickiness decreased. Based on these results, FIII (with 2% Carbopol 940) was concluded to meet the physical criteria for a secang leaf extract (Biancaea sappan L.) burn gel preparation. It exhibited a pH value of 6, a spread power of 5.5, an adhesion power of 1.38, and a viscosity of 275. Therefore, FIII is considered the most optimum gel formula.

Formulation Nail polish Cream preparations Extract Impatiens balsamina L

Teti Indrawati Indrawati, Fitri Ningsih — Thu, 17 Jul 2025 00:00:00 +0000

Secara tradisional daun Impatiens balsamina L digunakan sebagai pewarna kuku. Impatiens balsamina L mengandung flavonoid dan kuinon yang dapat digunakan sebagai pewarna kuku. Penelitian ini bertujuan untuk membuat sediaan krim cat kuku dari ekstrak daun inai. Penelitian dilakukan dengan membuat ekstrak daun segar Impatiens balsamina L secara maserasi menggunakan etanol 96%. Sediaan krim cat kuku dibuat dengan metode gom kering (metode kontinental) menggunakan basis Vanishing cream dengan konsentrasi ekstrak daun inai 5%, 10%, dan 15%. Krim yang dihasilkan kemudian dievaluasi organoleptik, jenis krim, pH, viskositas dan sifat alir, uji daya sebar, uji iritasi, uji kesukaan, dan uji daya lekat cat kuku. Krim yang dihasilkan bersifat homogen, berwarna kuning, jingga, jingga, dan merah jingga, serta bertipe O/W, pH antara 5,93-5,15 dengan sifat alir pseudoplastik dan viskositas 13000 cP-96000 cP. Penyebaran krim berkisar antara 23,1-29,35 mm, tidak mengiritasi kulit dan kuku, serta dapat menempel pada kuku hingga 3 minggu. Panelis lebih menyukai semua formula dan formula yang mengandung ekstrak henna 15 merupakan yang paling disukai. Kata kunci: Daun Impatiens balsamina L, Pewarna kuku, Krim

Efek Samping Obat Antituberkulosis (OAT) Lini Pertama pada Penderita TB Paru di Puskesmas X Kota Bekasi Periode Januari – Maret 2025

Wed, 06 Aug 2025 05:50:53 +0000

Tuberculosis is a disease caused by the bacteria Mycobacterium tuberculosis. This disease is still a health problem in the world. The most widely used therapy is First-line OAT. The use of this drug can cause side effects of the drug. The purpose of this study was to determine the side effects of using first-line OAT therapy drugs. This type of study is descriptive observational with a cross-sectional study design. The sampling technique used was consecutive sampling. with inclusion criteria of patients receiving first-line OAT treatment, aged 20-65 years old, patients with intensive or advanced treatment stages, patients with 1 week of treatment then the causality of drug side effects was analyzed using the naranjo algorithm. This study had a sample of 39 respondents who met the inclusion criteria, 62% male patients and 36% aged 20-29 years. As many as 56% were in the intensive treatment phase with the longest treatment duration being 1 month (26%). During the use of first-line OAT, 54% complained of nausea and vomiting, 18% joint pain, 56% red urine, 21% loss of appetite. The results of the causality analysis using the naranjo algorithm showed that the side effects experienced were included in the probable category. The use of first-line OAT in patients with pulmonary tuberculosis can cause side effects. This is stated using the causality analysis of the naranjo algorithm, showing a score of 5-8 (probable) which means the possibility of ESO due to the use of first-line OAT.

Drug Related Problems (DRPs) Study of ARI Treatment in Pediatrics at the Primary Clinic Bogor Regency Periode Januari-Desember 2021

Marina Notiasary, Tahoma Siregar — Wed, 06 Aug 2025 00:00:00 +0000

Drug Related Problems (DRPs) is a form of pharmaceutical service that looks for all drug-related problems in a treatment. The prevalence of Acute Respiratory Infection (ARI) in pediatrics in the 2019 Bogor District Health Profile report is still quite high, coupled with the high number of pediatric hospitalizations with ARI, making it one of the highest causes of death in pediatrics. This study aims to examine DRPs for the treatment of ARI in Pediatrics at the Primary Clinic, Bogor Regency in 2023. The method used in this research is a retrospective descriptive by reviewing patient medical records in 2021 with a purposive sampling design on 87 prescriptions with 555 prescribed drugs, the highest results showed that 84 (96.6%) prescriptions and 277 (50%) drugs experienced DRPs. Sample characteristics based on age in the 2 year-<12year category 55 (63.2%), the most gender was male 49 (56.3%), the most weight was in the thin category 48 (55.2%) and comorbidities as many as 17 (19.3%). The drug use profile includes the drug classes Antibiotics, Analgesics – Antipyretics, Antihistamines, Corticosteroids, Decongestants, Bronchodilators, Mucolytics/Expectorants, Antitussives, Combination drugs and Additional therapy. Conclution of Drug Related Problems (DRPs) Study at the Primary Clinic, Bogor Regency in 2021 in the category of Polypharmacy 78 (89.7%), Low Doses 252 (45.4%), High Doses 25 (4.5%), Indications without Drugs 14 (16.1%), Drugs Without Indications 18 (3, 4%), Potential for Drug Interaction with Drugs Most Moderate 144 (44%).

The Analytical Method Validation for Determination of Betamethasone and Dexchlorpheniramine Maleate Content in Syrup by UV-Vis Spectrophotometric Method

Anita Alodia, Herdini ., Ika Maruya Kusuma — Wed, 06 Aug 2025 08:20:33 +0000

Saat ini banyak beredar sediaan obat dengan lebih dari satu komponen zat aktif. Salah satu kombinasi yang digunakan yaitu betamethasone (kortikosteroid) dan dexchlorpheniramine maleate (antihistamin). Kombinasi ini cocok digunakan karena memberikan efek sinergis dalam mengatasi berbagai kondisi alergi dan peradangan serta memiliki risiko efek samping sedatif yang lebih rendah. Betamethasone dan dexchlorpheniramine maleate tersedia dalam bentuk sediaan tablet dan sirup dengan berbagai merek dagang dipasaran. Dalam penelitian ini akan dilakukan validasi metode analisis penetapan kadar betamethasone dan dexchlorpheniramine maleate dalam sediaan sirup menggunakan spektrofotometri UV-Vis. Metode spektrofotometri UV-Vis dipilih karena efisiensinya dalam memberikan hasil yang akurat dan presisi dibandingkan dengan metode lain. Pengujian yang dilakukan dalam penelitian ini sesuai dengan United States Pharmacopeia (USP 43-NF38) tahun 2020, dimana validasi metode analisis terbagi menjadi 4 kategori, dan penentuan kuantitas zat aktif suatu obat (penetapan kadar) masuk ke dalam skema validasi kategori 1 dengan meliputi berbagai parameter validasi, termasuk akurasi, presisi, spesifisitas, linearitas, dan ketahanan. Hasil menunjukkan bahwa metode spektrofotometri UV-Vis valid, dengan nilai akurasi kadar pada betamethasone sebesar 100,14% dan dexchlorpheniramine maleate sebesar 99,74%, presisi dengan %RSD < 2%, spesifisitas tanpa respon signifikan dari komponen lain, nilai r² = 0,99 pada pengujian linearitas, dan ketahanan dalam rentang variabel waktu 24 jam.

The Suitability of INR (International Normalized Ratio) of Atrial Fibrillation Patients with Warfarin Therapy in Hospital “X” Jakarta January - December 2024

Vivi Nur Aisyah, Chilyati Eky Futihat, Anisa Rachmita Arianti — Sat, 09 Aug 2025 06:14:10 +0000

Atrial fibrillation is a supraventricular arrhythmia with irregular atrial activation. One of the therapies that can be given is vitamin K antagonist class anticoagulants, namely warfarin. Bleeding often occurs in patients receiving warfarin therapy, so the use of anticoagulants must be balanced with an examination of the International Normalized Ratio. This study aims to evaluate the relationship between warfarin dose and the International Normalized Ratio value of atrial fibrillation patients at “X” hospital in Jakarta. The method used was a non-experimental analytic, cross-sectional design using medical record data. Data were processed using SPSS version 25 with the Spearman Rank method. The inclusion criteria used in this study were outpatients with a diagnosis of atrial fibrillation, aged 25 to ≥ 85 years, receiving warfarin therapy, and having complete laboratory examination results, including International Normalized Ratio values. The number of samples that met the inclusion criteria was 60 patients. The results showed that patients with warfarin therapy were more male patients, namely 31 patients (52%), the most age range was 55-64 years (38%), most International Normalized Ratio examinations were carried out 1-4 times a year (73%), and patients with an International Normalized Ratio value of 2-3 were 13 people (21%). Statistical tests showed no significant relationship between warfarin dose and International Normalized Ratio value, the p value obtained was 0.164, which means that there is no significant relationship between the difference in the use of warfarin doses in atrial fibrillation patients at “X” Hospital Jakarta, January - December 2024, to the suitability of INR values.