https://ejournal.istn.ac.id/index.php/saintechfarma/issue/feed 2025-03-13T00:41:26+00:00 Vilya Syafriana sainstechfarma@istn.ac.id Open Journal Systems <p>Sainstech Farma adalah jurnal yang memuat artikel-artikel terseleksi dari hasil penelitian dan kajian pustaka berbasis pengetahuan yang terkait dengan bidang kefarmasian. Artikel berasal dari penulis yang berafiliasi dengan Universitas, Lembaga Penelitian, dan Lembaga Pemerintah Non Departemen (LPND), atau lembaga-lembaga lain yang memiliki aktivitas dalam riset, ilmu pengetahuan, dan teknologi yang berkaitan dengan ilmu kefarmasian. Naskah yang diterima Redaksi Jurnal Sainstech Farma akan ditelaah dan diseleksi oleh Mitra Bestari dan Dewan Redaksi sesuai dengan bidang keahliannya. Jurnal Sainstech Farma terbit dua kali per tahun (Januari dan Juli).</p> <p>&nbsp;</p> https://ejournal.istn.ac.id/index.php/saintechfarma/article/view/2196 2025-02-28T13:16:30+00:00 Erwi Putri Setyaningsih erwi@istn.ac.id Resti Wulan Dari erwi@istn.ac.id Rosario Trijuliamos Manalu rio@istn.ac.id

<p><em>Breast cancer is a malignant tumor caused by excessive expression of one or all three estrogen (ER) and progesterone (PR) proteins and Human Epidermal Growth Factor Receptor (HER2). Current breast cancer treatment generally uses chemotherapy, radiotherapy, hormone therapy, and surgery. The increasing need for new drugs with high selectivity, low toxicity, and good metabolic stability against breast cancer has led many researchers to explore Indonesia's natural resources to obtain drugs that have anticancer activity. Chalcone is a secondary metabolite of the flavonoid group with pharmacological activity as an anticancer. Four chalcone compounds in jambu air leaves (Eugenia aquea Burm f) have met the requirement</em></p> <p><em>Breast cancer is a malignant tumor caused by excessive expression of one or all three estrogen (ER) and progesterone (PR) proteins and Human Epidermal Growth Factor Receptor (HER2). Current breast cancer treatment generally uses chemotherapy, radiotherapy, hormone therapy, and surgery. The increasing need for new drugs with high selectivity, low toxicity, and good metabolic stability against breast cancer has led many researchers to explore Indonesia's natural resources to obtain drugs that have anticancer activity. Chalcone is a secondary metabolite of the flavonoid group with pharmacological activity as an anticancer. Four chalcone compounds in jambu air leaves (Eugenia aquea Burm f) have met the requirements for drug similarity testing. In silico research is the initial step in designing new drug discoveries because it is relatively faster and can handle thousands of compounds. This study aimed to determine the activity and potential of jambu air (Eugenia aquea Burm f) leaf chalcone compounds in inhibiting the target protein of breast cancer T47D cells in silico and its ADMET prediction. The research method is in silico, with molecular docking techniques using the YASARA View, Marvinsketch, PubChem, PLANTS, and Discovery Studio 2021 applications. The results of the molecular docking analysis of the target protein, namely, Myrigalon-b have the potential to inhibit HER2 protein, Myrigalon-g has the potential to inhibit ERα, and phloretin has the potential to inhibit ERβ. The ADMET prediction results of the Myrigalon-g and phloretin compounds have the best values.&nbsp;&nbsp;</em></p>

2025-02-28T13:12:10+00:00 ##submission.copyrightStatement## https://ejournal.istn.ac.id/index.php/saintechfarma/article/view/2245 2025-03-13T00:41:26+00:00 Ritha widyapratiwi ritha@istn.ac.id Amelia Febriani ameliafebriani@istn.ac.id Fadia Husna ritha@istn.ac.id

<p>The <em>completeness of prescription review must be carried out to prevent the occurrence of medication errors in &nbsp;e-prescription services. This study aims to determine the results of the study of the completeness of outpatient&nbsp; e- prescriptions for general poly patients at the Petir Public Health Center Tangerang City. This type of research is descriptive with a cross sectional approach and retrospective sampling with a total sample of 330 e- prescriptions. The results showed the completeness of the e-prescription administration in the patient's name 100%, age 100%, gender 100%, weight 99.70%, doctor's name 100%, doctor's SIP 56%, doctor's paraf 100%, and date of prescription writing 100%. In pharmaceutical terms, the dosage form 96.06%, dosage strength 98.48%, quantity of drugs 100%, rules and methods of use 97.27%, and incompatibility 100%. In clinical terms, the accuracy of dosage 88.18% and the potential for drug interactions 34.24% ,with 38.64% low interaction potential and 61.36% moderate interaction potential . It is hoped that the results of this study will encourage doctors and pharmacists to pay more attention to the completeness of&nbsp; e-prescriptions, thereby improving the service to patients, ensuring that treatment is adhered to and preventing medication errors in&nbsp; e-prescribing.</em></p>

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