Efek Samping Obat Antituberkulosis (OAT) Lini Pertama pada Penderita TB Paru di Puskesmas X Kota Bekasi Periode Januari – Maret 2025
Keywords:
Bahasa Indonesia
Abstract
Tuberculosis is a disease caused by the bacteria Mycobacterium tuberculosis. This disease is still a health problem in the world. The most widely used therapy is First-line OAT. The use of this drug can cause side effects of the drug. The purpose of this study was to determine the side effects of using first-line OAT therapy drugs. This type of study is descriptive observational with a cross-sectional study design. The sampling technique used was consecutive sampling. with inclusion criteria of patients receiving first-line OAT treatment, aged 20-65 years old, patients with intensive or advanced treatment stages, patients with 1 week of treatment then the causality of drug side effects was analyzed using the naranjo algorithm. This study had a sample of 39 respondents who met the inclusion criteria, 62% male patients and 36% aged 20-29 years. As many as 56% were in the intensive treatment phase with the longest treatment duration being 1 month (26%). During the use of first-line OAT, 54% complained of nausea and vomiting, 18% joint pain, 56% red urine, 21% loss of appetite. The results of the causality analysis using the naranjo algorithm showed that the side effects experienced were included in the probable category. The use of first-line OAT in patients with pulmonary tuberculosis can cause side effects. This is stated using the causality analysis of the naranjo algorithm, showing a score of 5-8 (probable) which means the possibility of ESO due to the use of first-line OAT.References
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Khairunnisa, S. A., & Puspitasari, I. M. (2023). Review : Efek Samping Obat Antituberkulosis Oral Lini Pertama Pada Anak. Farmaka, 21(2), 197–205.
Kristiani, W., Kristiani, W., Kurniawati, D., Saputri, R., Sari, U., & Banjarmasin, M. (2019). Monitoring Efek Samping Obat Tuberkulosis DI. 26–42.
Mafukidze, A. T., Calnan, M., & Furin, J. (2020). Peripheral neuropathy in persons with tuberculosis. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2, 5–11. https://doi.org/10.1016/j.jctube.2015.11.002
Maulitha, F., Fitriani, N., & Rusli, R. (2022). Analisis Efek Samping Penggunaan Obat Antituberkulosis (OAT) di Instalasi Rawat Jalan RSD BLUD dr. H. Soemarno Sosroatmodjo Tanjung Selor. Proceeding of Mulawarman Pharmaceuticals Conferences, 16(November), 1–8. https://doi.org/10.25026/mpc.v16i1.656
Musdalipah, Nurhikmah, E., Karmilah, & Fakhrurazi, M. (2018). Efek Samping Obat Anti Tuberkulosis ( Oat ) Dan Penanganannya Pada Pasien Tuberkulosis ( Tb ) Di. Jurnal Imiah Manuntun, 4(1), 67–73. https://doi.org/10.51352/jim.v4i1.144
Mustikawangi, V., Rambert, G., & Wowor, M. (2016). Gambaran pemeriksaan makroskopis urin pada pasien tuberkulosis paru. Journal E-Biomedik (EBm), 4(2).
Nasichah, S. N. A., & Kristinawati, B. (2024). Hubungan Efek Samping Obat Anti Tuberkulosis dan Penyakit Penyerta dengan Kualitas Hidup Pasien Tuberkulosis Paru. Journal of Telenursing (JOTING), 6(1), 104–112. https://journal.ipm2kpe.or.id/index.php/JOTING/article/view/8565
Nazir, T., Farhat, S., Adil, M., & Asraf, Z. (2018). Adverse drug reactions associated with first line anti-tubercular drugs, their prevalence and causality assessment in patients on Directly Observed Treatment Short-course (DOTS) in a tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 8(1), 147. https://doi.org/10.18203/2319-2003.ijbcp20185174
Ningsih, A. S. W., Ramadhan, A. M., & Rahmawati, D. (2022). Kajian Literatur Pengobatan Tuberkulosis Paru dan Efek Samping Obat Antituberkulosis di Indonesia. Proceeding of Mulawarman Pharmaceuticals Conferences, 15, 231–241. https://doi.org/10.25026/mpc.v15i1.647
Nita, Y., Budiman, H., & Sari, E. (2023). Hubungan Pengetahuan, Kebiasaan Merokok Dan Riwayat Kontak Serumah Dengan Kejadian Tb Paru. Human Care Journal, 7(3), 724. https://doi.org/10.32883/hcj.v7i3.2060
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Pratiwi, E. P., Rohmawaty, E., & Kulsum, I. D. (2018). Efek Samping Obat Anti Tuberkulosis Kategori I dan II Pasien Tuberkolosis Paru Dewasa di Rumah Sakit Hasan Sadikin. Indonesian Journal of Clinical Pharmacy, 7(4), 252. https://doi.org/10.15416/ijcp.2018.7.4.252
Pratiwi, I. A. (2022). Hubungan Efek Samping Obat Anti Tuberkulosis (Oat) Terhadap Kepatuhan Minum Obat Pada Pasien Tb Paru Di Puskesmas. 8(2), 123–131. https://www.mendeley.com/catalogue/15c35e08-12a5-3771-8856-a55a0cae23f1/?utm_source=desktop&utm_medium=1.19.8&utm_campaign=open_catalog&userDocumentId=%7B9dda6999-a7d6-476e-908c-8e71fde69557%7D#abstract-title
Putri, V. R., Muslim, Z., & Susilo, A. I. (2024). Analisis Kejadian Efek Samping Obat Anti Tuberkulosis Di Kota Bengkulu. Journal of Nursing and Public Health, 12(1), 187–192. https://doi.org/10.37676/jnph.v12i1.6368
Rasdianah, N., Madania, Tutoli, T. S., Abdulkadir, W. S., Hidayat, A., & Suwandi, T. B. A. (2022). Studi Efek Samping Obat Antituberkulosis ( OAT ) Pada Pasien TB Paru. Journal Syifa Sciences and Clinical Research (JSSCR), 4(3), 707–717.
Rosamarlina, R., Lisdawati, V., Banggai, C. E., Darayani, D., Pakki, T. R., Rogayah, R., & Murtiani, F. (2019). Monitoring Efek Samping Obat Anti Tuberkulosis di Poli TB DOTS RSPI Prof. Dr. Sulianti Saroso. The Indonesian Journal of Infectious Diseases, 5(2), 10–20. https://doi.org/10.32667/ijid.v5i2.81
Suarni, E., Rosita, Y., & Irawanda, V. (2019). Implemen tasi Terapi DOTS ( Directly Observed Treatment Short- Course ) pada TB Paru di RS Muhammadiyah Palembang Pendahuluan Penyakit Pengobatan dan pengendalian TB di menerapkan manajemen operasional Organization ( WHO ) yaitu strategi Strategi DOTS dia. Syifa’MEDIKA, 3(2).
Sunarmi, S., & Kurniawaty, K. (2022). Hubungan Karakteristik Pasien Tb Paru Dengan Kejadian Tuberkulosis. Jurnal ’Aisyiyah Medika, 7(2), 182–187. https://doi.org/10.36729/jam.v7i2.865
Weiangkham, D., Umnuaypornlert, A., Saokaew, S., Prommongkol, S., & Ponmark, J. (2022). Effect of alcohol consumption on relapse outcomes among tuberculosis patients: A systematic review and meta-analysis. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.962809
Agus Nurjana. Made. (2018). Faktor Risiko Terjadinya Tuberculosis Paru Usia Produktif (15-49 Tahun) Di Indonesia Risk Factors of Pulmonary Tuberculosis on Productive Age 15-49 Years Old in Indonesia. Media Litbangkes, 25, 165–170.
Andriani, E. K., Harahap, N. R. A., & Wahyu Nuraini Hasmar. (2022). Evaluasi Pengobatan Anti Tuberkulosis Pada Pasien Geriatri Rawat Jalan Di Rumah Sakit Swasta Wilayah Bekasi Timur Tahun 2020-2021. Jurnal Mitra Kesehatan, 5(1), 9–17. https://doi.org/10.47522/jmk.v5i1.144
Asriwati, Yeti, E., Niakurniawati, & Usman, A. N. (2021). Risk factors analysis of non-compliance of Tuberculosis (TB) patients taking medicine in Puskesmas Polonia, Medan, 2021. Gaceta Sanitaria, 35, S227–S230. https://doi.org/10.1016/j.gaceta.2021.10.027
Baliasa, W., Pingkan, W., Kaunang, J., Harold, B., & Kairupan, R. (2020). Hubungan Pengetahuan, Sikap dan Tindakan Penderita Tuberkulosis dengan Hasil Terapi di Puskesmas Biak Banggai. Journal of Public Health and Community Medicine, 1(4), 63–69.
Fraga, A. (2021). Evaluasi Penggunaan Obat Anti Tuberkulosis Pasien Baru Tuberkulosis Paru Di Puskesmas Oebobo Kupang Tahun 2020. Jurnal Farmagazine, VIII(1), 17–24.
Gumanti, S. T. A., L. C. P., D., & Rifkia, V. (2022). Monitoring efek samping obat antituberkulosis fase intensif dan lanjutan pasien dewasa tuberkulosis di RSUD Kota Bandung. JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X, 12(1), 86–93. https://doi.org/10.35617/jfionline.v12i1.52
Heti Rais Khasanah, Nadia Pudiarifanti, Elda Meliyarta, A. N. I. (2024). Efek Samping penggunaan obat anti tuberkulosis di puskesmas kota bengkulu tahun 2024. 14(3), 91–96. 10.36085/avicenna.v14i3.638
Iwan Efendi, Alwin Widhiyanto, & Ainul Yaqin Salam. (2023). Hubungan Efek Samping Obat Anti Tuberkulosis Dengan Kualitas Hidup Pasien TB Di Puskesmas Banyuglugur Situbondo. DIAGNOSA: Jurnal Ilmu Kesehatan Dan Keperawatan, 1(4), 248–263. https://doi.org/10.59581/diagnosa-widyakarya.v1i4.1333
Kakilla, C. (2021). Strengths and Weaknesses of Semi-Structured Interviews in Qualitative Research: A Critical Essay Charles Kakilla Atlantia Clinical Trials Strengths and Weaknesses of Semi-Structured Interviews in Qualitative Research: A Critical Essay. June, 0–4. https://doi.org/10.20944/preprints202106.0491.v1
Kemenkes RI. (2020). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. Kementrian Kesehatan Republik Indonesia.
Kemenkes RI. (2023). Profil Kesehatan Penyakit Di Indonesia. Kementrian Kesehatan Republik Indonesia.
Kemenkes RI, 2016. (2016). Penanggulangan Tuberkulosis. Kementrian Kesehatan Respublik Indonesia.
Khairunnisa, S. A., & Puspitasari, I. M. (2023). Review : Efek Samping Obat Antituberkulosis Oral Lini Pertama Pada Anak. Farmaka, 21(2), 197–205.
Kristiani, W., Kristiani, W., Kurniawati, D., Saputri, R., Sari, U., & Banjarmasin, M. (2019). Monitoring Efek Samping Obat Tuberkulosis DI. 26–42.
Mafukidze, A. T., Calnan, M., & Furin, J. (2020). Peripheral neuropathy in persons with tuberculosis. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2, 5–11. https://doi.org/10.1016/j.jctube.2015.11.002
Maulitha, F., Fitriani, N., & Rusli, R. (2022). Analisis Efek Samping Penggunaan Obat Antituberkulosis (OAT) di Instalasi Rawat Jalan RSD BLUD dr. H. Soemarno Sosroatmodjo Tanjung Selor. Proceeding of Mulawarman Pharmaceuticals Conferences, 16(November), 1–8. https://doi.org/10.25026/mpc.v16i1.656
Musdalipah, Nurhikmah, E., Karmilah, & Fakhrurazi, M. (2018). Efek Samping Obat Anti Tuberkulosis ( Oat ) Dan Penanganannya Pada Pasien Tuberkulosis ( Tb ) Di. Jurnal Imiah Manuntun, 4(1), 67–73. https://doi.org/10.51352/jim.v4i1.144
Mustikawangi, V., Rambert, G., & Wowor, M. (2016). Gambaran pemeriksaan makroskopis urin pada pasien tuberkulosis paru. Journal E-Biomedik (EBm), 4(2).
Nasichah, S. N. A., & Kristinawati, B. (2024). Hubungan Efek Samping Obat Anti Tuberkulosis dan Penyakit Penyerta dengan Kualitas Hidup Pasien Tuberkulosis Paru. Journal of Telenursing (JOTING), 6(1), 104–112. https://journal.ipm2kpe.or.id/index.php/JOTING/article/view/8565
Nazir, T., Farhat, S., Adil, M., & Asraf, Z. (2018). Adverse drug reactions associated with first line anti-tubercular drugs, their prevalence and causality assessment in patients on Directly Observed Treatment Short-course (DOTS) in a tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 8(1), 147. https://doi.org/10.18203/2319-2003.ijbcp20185174
Ningsih, A. S. W., Ramadhan, A. M., & Rahmawati, D. (2022). Kajian Literatur Pengobatan Tuberkulosis Paru dan Efek Samping Obat Antituberkulosis di Indonesia. Proceeding of Mulawarman Pharmaceuticals Conferences, 15, 231–241. https://doi.org/10.25026/mpc.v15i1.647
Nita, Y., Budiman, H., & Sari, E. (2023). Hubungan Pengetahuan, Kebiasaan Merokok Dan Riwayat Kontak Serumah Dengan Kejadian Tb Paru. Human Care Journal, 7(3), 724. https://doi.org/10.32883/hcj.v7i3.2060
Pangaribuan, L., Kristina, K., Perwitasari, D., Tejayanti, T., & Lolong, D. B. (2020). Faktor-Faktor yang Mempengaruhi Kejadian Tuberkulosis pada Umur 15 Tahun ke Atas di Indonesia. Buletin Penelitian Sistem Kesehatan, 23(1), 10–17. https://doi.org/10.22435/hsr.v23i1.2594
Pratiwi, E. P., Rohmawaty, E., & Kulsum, I. D. (2018). Efek Samping Obat Anti Tuberkulosis Kategori I dan II Pasien Tuberkolosis Paru Dewasa di Rumah Sakit Hasan Sadikin. Indonesian Journal of Clinical Pharmacy, 7(4), 252. https://doi.org/10.15416/ijcp.2018.7.4.252
Pratiwi, I. A. (2022). Hubungan Efek Samping Obat Anti Tuberkulosis (Oat) Terhadap Kepatuhan Minum Obat Pada Pasien Tb Paru Di Puskesmas. 8(2), 123–131. https://www.mendeley.com/catalogue/15c35e08-12a5-3771-8856-a55a0cae23f1/?utm_source=desktop&utm_medium=1.19.8&utm_campaign=open_catalog&userDocumentId=%7B9dda6999-a7d6-476e-908c-8e71fde69557%7D#abstract-title
Putri, V. R., Muslim, Z., & Susilo, A. I. (2024). Analisis Kejadian Efek Samping Obat Anti Tuberkulosis Di Kota Bengkulu. Journal of Nursing and Public Health, 12(1), 187–192. https://doi.org/10.37676/jnph.v12i1.6368
Rasdianah, N., Madania, Tutoli, T. S., Abdulkadir, W. S., Hidayat, A., & Suwandi, T. B. A. (2022). Studi Efek Samping Obat Antituberkulosis ( OAT ) Pada Pasien TB Paru. Journal Syifa Sciences and Clinical Research (JSSCR), 4(3), 707–717.
Rosamarlina, R., Lisdawati, V., Banggai, C. E., Darayani, D., Pakki, T. R., Rogayah, R., & Murtiani, F. (2019). Monitoring Efek Samping Obat Anti Tuberkulosis di Poli TB DOTS RSPI Prof. Dr. Sulianti Saroso. The Indonesian Journal of Infectious Diseases, 5(2), 10–20. https://doi.org/10.32667/ijid.v5i2.81
Suarni, E., Rosita, Y., & Irawanda, V. (2019). Implemen tasi Terapi DOTS ( Directly Observed Treatment Short- Course ) pada TB Paru di RS Muhammadiyah Palembang Pendahuluan Penyakit Pengobatan dan pengendalian TB di menerapkan manajemen operasional Organization ( WHO ) yaitu strategi Strategi DOTS dia. Syifa’MEDIKA, 3(2).
Sunarmi, S., & Kurniawaty, K. (2022). Hubungan Karakteristik Pasien Tb Paru Dengan Kejadian Tuberkulosis. Jurnal ’Aisyiyah Medika, 7(2), 182–187. https://doi.org/10.36729/jam.v7i2.865
Weiangkham, D., Umnuaypornlert, A., Saokaew, S., Prommongkol, S., & Ponmark, J. (2022). Effect of alcohol consumption on relapse outcomes among tuberculosis patients: A systematic review and meta-analysis. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.962809
Published
2025-08-06
How to Cite
Kamila, A. S., Futihat, C. E., Arianti, A. R., & ., M. (2025). Efek Samping Obat Antituberkulosis (OAT) Lini Pertama pada Penderita TB Paru di Puskesmas X Kota Bekasi Periode Januari – Maret 2025. Sainstech Farma: Jurnal Ilmu Kefarmasian, 18(2), 64-71. https://doi.org/https://doi.org/10.37277/sfj.v18i2.2354
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