Prophylactic Antibiotic Use Profile of Caesarean Section in X Hospital West Java
Keywords:
Antibiotic Use Guidelines, Antimicrobial Stewardship, caesarean section, prophylactic antibiotic
Abstract
Prophylactic antibiotics are antibiotics given before, during and up to 24 hours after surgery in cases where clinically there are no signs of infection with the aim of preventing surgical site infection. Caesarean Section (CS) prophylactic antibiotics are antibiotics given to prevent post-CS infections. This study aims to evaluate compliance of CS prophylactic antibiotics use with the Hospital X West Java’s Antibiotic Use Guidelines, especially regarding the use of CS prophylactic antibiotics. This research is descriptive quantitative with retrospective data collection. The subjects observed in this study were medical record documents and CS patient registration books at X Hospital in West Java on first semester of 2024. All of CS patient are inventarised that consist of patient and doctor identity and prophylactic antibiotics usage. The result was average of compliance with the selection and administration of prophylactic CS antibiotic doses according to Antibiotic Use Guidelines were 18.97% and 1.58%, compliance with the route of administering CS prophylactic antibiotic doses according to Antibiotic Use Guidelines was 100%, average of with administering CS prophylactic antibiotics 30-60 minutes before CS taken was 36.33% and average of single dose CS antibiotic prophylaxis given was 41.48%. Compliance with the use of CS prophylactic antibiotics at Hospital X West Java according to Antibiotic Use Guidelines was very poor.References
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Muzayyanah, B., Yulistiani, Y., Hasmono, D., & Wisudani. N. (2018). Analysis of Prophylactic Antibiotics Usage in Caesarean Section Delivery. Folia Medica Indonesiana, 54(3), 161-166.
Nabhan, A.F., Allam, N.E., & Salama, M.H.A. (2016). Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD011876.pub2.
Nitrushwa, D., Ghebre, R., Unyuzimana, M.A., Magriples U., Small, M., & Rulisa, S. (2021). Single vs. extended antibiotic for prevention of surgical infection in emergent cesarean delivery. International Journal of Pregnancy & Child Birth, 7(2), 51–56.
Oktaviani, F., Wahyono, D., & Yuniarti, E. (2015). Evaluasi Penggunaan Antibiotik Profilaksis terhadap Kejadian Infeksi Luka Operasi pada Operasi Sectio Caesarea. Jurnal Manajemen dan Pelayanan Farmasi, 5(4), 255-258.
Perkumpulan Obstetri Ginekologi Indonesia [POGI]. (2013). Panduan Antibiotik Profilaksis pada Pembedahan Obstetri Ginekologi.
Reiff, E.S., Habib, A.S., Carvalho, B., & Raghunathan, K. (2020). Antibiotic Prophylaxis for Cesarean Delivery: A Survey of Anesthesiologists. Anesthesiology Research and Practice. doi: 10.1155/2020/3741608.
Rumah Sakit X Jawa Barat. (2018). Panduan Penggunaan Antibiotik.
Schalkwyk, J.V. & Eyk, N.V. (2017). Antibiotic Prophylaxis in Obstetric Procedures. Journal of Obstetrics and Gynaecology Canada, 39(9), 293-299. doi: 10.1016/j.jogc.2017.06.007
Smaill, F. & Hofmeyr, G.J. (2002). Antibiotic prophylaxis for cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD000933.
Smaill, F.M. & Grivell, R.M. (2014). Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD007482.pub3.
Viamonte, K.R., Tames, A.S., Correa, R.S., Manteca, M.V.R., & Suárez, A.M. (2021). Compliance with antibiotic prophylaxis guidelines in caesarean delivery: a retrospective, drug utilization study (indication-prescription type) at an Ecuadorian hospital. Antimicrobial Resistance and Infection Control. 10(1):12. doi: 10.1186/s13756-020-00843-1.
World Health Organization [WHO]. (2021). WHO recommendation on Prophylactic antibiotics for women undergoing caesarean section.
Yeung, J.., Pauls, R., & Crisp, C. (2016). Appropriate Timing of Prophylactic Antibiotics at Cesarean Delivery [23D]. Obstetrics and Gynecology. doi:10.1097/01.AOG.0000483401.02399.0a.
Al-Momany, N.H., Al-Bakri, A.G., Makahleh, Z. M., & Wazaify. M.M.B. (2009). Adherence to international antimicrobial prophylaxis guidelines in cardiac surgery: a Jordanian study demonstrates need for quality improvement. Journal of managed care pharmacy, 15(3), 262-71. doi: 10.18553/jmcp.2009.15.3.262.
American Society of Health-System Pharmacist [ASHP]. (2024). Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Diambil dari https://www.ashp.org/pharmacy-practice/policy-positions-and-guidelines/browse-by-document-type/therapeutic-guidelines?loginreturnUrl=SSOCheckOnly. (diakses pada 31 Mei 2024).
American College of Obstetricians and Gynecologists. (2011). ACOG Practice Bulletin No. 120: Use of prophylactic antibiotics in labor and delivery. 117(6),1472-1483. doi: 10.1097/AOG.0b013e3182238c31.
Berghella, V., Baxter, J.K., & Chauhan, S.P. (2005). Evidence-based surgery for cesarean delivery. American journal of obstetrics and gynecology, 193(5), 1607-17. doi: 10.1016/j.ajog.2005.03.063.
Bratzler, D.W., Dellinger, E.P., Olsen, K.M., Perl, T.M., Auwaerter, P.G., Bolon, M.K., et al. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surgical infections, 14(1), 73-156. doi: 10.1089/sur.2013.9999. Epub 2013 Mar 5.
Dayana, M., Nurmainah, & Untari, E.K.. (2019). Gambaran Penggunaan Antibiotik Profilaksis pada Pasien Sectio Caesarea di Rumah Sakit Universitas Tangjungpura Tahun 2017. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 4(1), 1-12.
Fanani, Z., Aisah, N., & Ridwana. (2022). Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Operasi Sectio Caesarea di RSU Islam Klaten tahun 2020. Indonesia Jurnal Farmasi, 7(1), 33-37.
Huang, Y., Yin, X., Wang, X., Zhou, F., Cao, X., Han, Y., et al. (2022). Is a single dose of commonly used antibiotics effective in preventing maternal infection after cesarean section? A network meta-analysis. Public Library of Science. doi: 10.1371/journal.pone.0264438. eCollection 2022.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. (2011). Peraturan Menteri Kesehatan Republik Indonesia No. 2406/MENKES/PER/XII/2011 tentang Pedoman Umum Penggunaan Antibiotika.
Kementerian Kesehatan Republik Indonesia [Kemenkes RI]. (2021). Peraturan Menteri Kesehatan Republik Indonesia No. 28 tahun 2021 tentang Pedoman Penggunaan Antibiotika.
Lamfel, R., Snyman, L., Seopela, L., Jahn, G., & Becker, P. (2024). Early online. South African Medical Journal, 114(5), e1081. doi: 10.7196/SAMJ.2024.v114i6.2232.
Makani, M. & Andayani, T.M. (2019). Pengaruh Pemberian Antibiotik Profilaksis Terhadap Infeksi Luka Operasi pada Pasien Bedah Obstetri dan Ginekologi di RSUP Dr. Sardjito. Majalah Farmaseutik, 17(1), 29-37.
Mackeen, A.D., Packard, R.E., Ota, E., Berghella, V., & Baxter, J.K. (2014). Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. The Cochrane database of systematic reviews. doi: 10.1002/14651858.CD009516.pub2.
Moore, J., Navarro, S., McCarthy, K., Rashid, R.B., Phipps, S., Amoako, A., et al. (2023). State of the art: Intrapartum antibiotics in cesarean section, the infant microbiota and allergic diseases. Acta Obstetricia et Gynecologica Scandinavica, 102, 811–820. doi: 10.1111/aogs.14577.
Muzayyanah, B., Yulistiani, Y., Hasmono, D., & Wisudani. N. (2018). Analysis of Prophylactic Antibiotics Usage in Caesarean Section Delivery. Folia Medica Indonesiana, 54(3), 161-166.
Nabhan, A.F., Allam, N.E., & Salama, M.H.A. (2016). Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD011876.pub2.
Nitrushwa, D., Ghebre, R., Unyuzimana, M.A., Magriples U., Small, M., & Rulisa, S. (2021). Single vs. extended antibiotic for prevention of surgical infection in emergent cesarean delivery. International Journal of Pregnancy & Child Birth, 7(2), 51–56.
Oktaviani, F., Wahyono, D., & Yuniarti, E. (2015). Evaluasi Penggunaan Antibiotik Profilaksis terhadap Kejadian Infeksi Luka Operasi pada Operasi Sectio Caesarea. Jurnal Manajemen dan Pelayanan Farmasi, 5(4), 255-258.
Perkumpulan Obstetri Ginekologi Indonesia [POGI]. (2013). Panduan Antibiotik Profilaksis pada Pembedahan Obstetri Ginekologi.
Reiff, E.S., Habib, A.S., Carvalho, B., & Raghunathan, K. (2020). Antibiotic Prophylaxis for Cesarean Delivery: A Survey of Anesthesiologists. Anesthesiology Research and Practice. doi: 10.1155/2020/3741608.
Rumah Sakit X Jawa Barat. (2018). Panduan Penggunaan Antibiotik.
Schalkwyk, J.V. & Eyk, N.V. (2017). Antibiotic Prophylaxis in Obstetric Procedures. Journal of Obstetrics and Gynaecology Canada, 39(9), 293-299. doi: 10.1016/j.jogc.2017.06.007
Smaill, F. & Hofmeyr, G.J. (2002). Antibiotic prophylaxis for cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD000933.
Smaill, F.M. & Grivell, R.M. (2014). Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section. The Cochrane Database of Systematic Reviews. doi: 10.1002/14651858.CD007482.pub3.
Viamonte, K.R., Tames, A.S., Correa, R.S., Manteca, M.V.R., & Suárez, A.M. (2021). Compliance with antibiotic prophylaxis guidelines in caesarean delivery: a retrospective, drug utilization study (indication-prescription type) at an Ecuadorian hospital. Antimicrobial Resistance and Infection Control. 10(1):12. doi: 10.1186/s13756-020-00843-1.
World Health Organization [WHO]. (2021). WHO recommendation on Prophylactic antibiotics for women undergoing caesarean section.
Yeung, J.., Pauls, R., & Crisp, C. (2016). Appropriate Timing of Prophylactic Antibiotics at Cesarean Delivery [23D]. Obstetrics and Gynecology. doi:10.1097/01.AOG.0000483401.02399.0a.
Published
2024-09-13
How to Cite
Hasanah, K. (2024). Prophylactic Antibiotic Use Profile of Caesarean Section in X Hospital West Java. Sainstech Farma: Jurnal Ilmu Kefarmasian, 17(2), 80-87. https://doi.org/https://doi.org/10.37277/sfj.v17i2.2001
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Articles
