Review: The Utilization of Nanoscience and Nanotechnology to Increase the Effectiveness of Drugs
Keywords:
efektivitas obat, nanosains, nanoteknologi, sistem penghantaran obat
Abstract
Science and nanotechnology in the pharmaceutical field, among others, are used to increase drug effectiveness and optimal safety. The research was conducted using the review method with the aim of this study to obtain information about the utilization of nanoscience and nanotechnology which can be used as reference material for development in the pharmaceutical field. Nano-drug delivery system technology is carried out by developing materials used both from natural origin, synthetic, and semi-synthetic as well as developing drug delivery systems. Nano-drug delivery system technology or known as smart drugs promises a very bright future through various modifications of drug dosage forms developed from conventional dosage forms to dosage forms with drug delivery systems with controlled drug release. Nano-drugs with nano-delivery systems can be made using carriers in the form of natural polymers, or synthetic ones that can be biodegradable or non-biodegradable. Efficient therapy using nanotechnology is carried out in order to increase the safety level of the drug, as well as the ability of the drug to reach its target with minimal side effects. There are three ways to do this: increasing the solubility and bioavailability of drugs, creating new dosage forms, and using better routes of administration. Nanotechnology has great potential in contributing to the national economy and the nation's competitiveness, although much needs to be done to transform scientific and technological excellence into the economic field.References
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Choudbury, D., Dutta, K.N., & Kalita, R. (2021). A Review on Transdermal Patches Used As an Anti-Inflammatory Agent. Asian Journal of Pharmaceutical and Clinical Research, 14(12), 21–26. https://doi.org/10.22159/ajpcr.2021.v14i12.43277
De Jong, W.H. & Borm, P.J.A. (2008). Drug delivery and nanoparticles: Applications and hazards. International Journal of Nanomedicine, 3(2), 133–149. https://doi.org/10.2147/IJN.S596
Delgado-Charro, M.B. & Guy, R.H. (2014). Effective use of transdermal drug delivery in children. Advanced Drug Delivery Reviews, 73, 63–82. https://doi.org/10.1016/j.addr.2013.11.014
Franco, P. & De Marco, I. (2020). The use of poly(N-vinyl pyrrolidone) in the delivery of drugs: A review. Polymers, 12(5), 18–21. https://doi.org/10.3390/POLYM12051114
Indermun, S., Choonara, Y.E., Kumar, P., Du Toit, L.C., Modi, G., Luttge, R., & Pillay, V. (2014). Patient-controlled analgesia: Therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery. Journal of Pharmaceutical Sciences, 103(2), 353–366. https://doi.org/10.1002/jps.23829
Indrawati, T. (2011). Sistem Penghantaran Obat Baru Peroral Dengan Pelepasan Terkontrol. Ilmu Kefarmasian, 2(1), 27–31.
Indrawati, T. (2014). Peluang dan Tantangan Aplikasi Nanoteknologi dan Nanosains pada Sistem Penghantaran Obat Sebagai Penentu Daya Saing Bangsa.
Indrawati, T. (2016). Pemanfaatan Sumber Daya Alam Melalui Sistem Penghantaran Obat dan Kosmetik (No. 3; 1).
Indrawati, T., Hakim, Z.R., & Fatimah, F. (2022). Developing transdermal patch from Momordica charantia L . fruit using polyvinyl alcohol and ethyl cellulose potentially as anti-inflammatory dosage form. 13.
Jain, S., Patel, N., Shah, M.K., Khatri, P., & Vora, N. (2017). Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application. Journal of Pharmaceutical Sciences, 106(2), 423–445. https://doi.org/10.1016/j.xphs.2016.10.001
Junod, S. W., & Beaver, W. T. (2008). FDA and Clinical Drug Trials: A Short History. Quick Guide to Clinical Trials, 25–55. www.fda.gov
McConville, A., Atchison, J., Roddy, A., & Davis, J. (2019). A wireless smart patch for the controlled repetitive transdermal administration of therapeutic agents. Sensors and Actuators, B: Chemical, 294, 24–31. https://doi.org/10.1016/j.snb.2019.05.023
Mokhena, T., Mochane, M., Tshwafo, M., Linganiso, L., Thekisoe, O., & Songca, S. (2016). We are IntechOpen , the world ’ s leading publisher of Open Access books Built by scientists , for scientists TOP 1 %. Intech, 225–240. https://www.intechopen.com/books/advanced-biometric-technologies/liveness-detection-in-biometrics
Ng, R. (2009). History of Drug Discovery and Development. Drugs: From Discovery to Approval, 391–397.
Parawansah, Wahyuni, & Mahmudah, Z. (2016). Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L .) terhadap Mencit Jantan. Jurnal Medula (Jurnal Ilmiah Fakultas Kedokteran Halu Oleo), 4(1), 309–315.
Pina, A. S., Hussain, A., & Roque, A. C. A. (2009). An historical overview of drug discovery. Methods in Molecular Biology, 572(1), 3–12. https://doi.org/10.1007/978-1-60761-244-5_1
Pratami, D. K., Indrawati, T., Istikomah, I., Farida, S., Pujianto, P., & Sahlan, M. (2020). Antifungal activity of microcapsule propolis from Tetragonula spp. To Candida albicans. Communications in Science and Technology, 5(1), 16–21. https://doi.org/10.21924/cst.5.1.2020.178
Sa’adon, S., Abd Razak, S. I., Ismail, A. E., & Fakhruddin, K. (2019). Fabrication of Dual Layer Polyvinyl Alcohol Transdermal Patch: Effect of Freezing-Thawing Cycles on Morphological and Swelling Ability. Procedia Computer Science, 158, 51–57. https://doi.org/10.1016/j.procs.2019.09.027
Shariatinia, Z., & Barzegari, A. (2019). Polysaccharide hydrogel films/membranes for transdermal delivery of therapeutics. In Polysaccharide Carriers for Drug Delivery. Elsevier Ltd. https://doi.org/10.1016/B978-0-08-102553-6.00022-2
Taylor, D. (2016). The pharmaceutical industry and the future of drug development. In Issues in Environmental Science and Technology (Vols. 2016-Janua, Issue 41). https://doi.org/10.1039/9781782622345-00001
Published
2023-07-31
How to Cite
Indrawati, T. (2023). Review: The Utilization of Nanoscience and Nanotechnology to Increase the Effectiveness of Drugs. Sainstech Farma: Jurnal Ilmu Kefarmasian, 16(2), 73-83. https://doi.org/https://doi.org/10.37277/sfj.v16i2.1682
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Articles
